Keep track of Closely (three)pentobarbital will lower the extent or outcome of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Powerful or moderate CYP3A4 inducers may well enhance fee of diazepam elimination; thus, efficacy of diazepam could possibly be decreased.
pentobarbital will lower the extent or result of diclofenac by impacting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Unknown.
pentobarbital will lessen the level or impact of conivaptan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will reduce the level or outcome of amiodarone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will reduce the extent or result of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Contraindications to pentobarbital use consist of prior hypersensitivity reactions to drug use or barbiturate class use. Barbiturates can cause hypersensitivity reactions by immediate histamine launch or immunoglobulin E (IgE)–mediated mechanisms and may result in anaphylaxis.
fentanyl transdermal and pentobarbital the two boost sedation. Avoid or Use Alternate Drug. Restrict use to individuals for whom alternate remedy possibilities are insufficient
pentobarbital will decrease the level or result of sunitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will minimize the extent or outcome of sildenafil by more info influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Potent CYP3A4 inducers are anticipated to result in significant decreases in sildenafil plasma ranges
Check Intently (one)pentobarbital will raise the stage or effect of clopidogrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Exercise warning when a barbiturate is administered to a nursing female; compact amounts of barbiturates are excreted while in the milk
Caution when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone might maximize and may end up in possibly fatal respiratory melancholy.
Using barbiturates as sedatives within the postoperative surgical period and as adjuncts to cancer chemotherapy is properly set up
pentobarbital will lower the extent or impact of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.